Condensation domain

In molecular biology, the condensation domain is a protein domain found in many multi-domain enzymes which synthesise peptide antibiotics. This domain catalyses a condensation reaction to form peptide bonds in non-ribosomal peptide biosynthesis. It is usually found to the carboxy side of a phosphopantetheine binding domain (pp-binding). It has been shown that mutations in the HHXXXDG sequence motif in this domain abolish activity suggesting this is part of the active site.^[1]

Condensation
crystal structure of vibh, an nrps condensation enzyme
Identifiers
Symbol	Condensation
Pfam	PF00668
Pfam clan	CL0149
InterPro	IPR001242
SCOP2	1l5a / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary