Conopharyngine

Not to be confused with Conopharyngia elegans.

Conopharyngine is the major alkaloid present in the leaves and stem-bark of Tabernaemontana pachysiphon and Conopharyngia durissima.^[1][2][3] It is closely related voacangine and coronaridine. Conopharyngine pseudoindoxyl, a derivative of it, is also found in the same plant Tabernaemontana pachysiphon.^[4]

Conopharyngine

Names
IUPAC name Methyl (1S,15S,17S,18S)-17-ethyl-6,7-dimethoxy-3,13-diazapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4,6,8-tetraene-1-carboxylate
Identifiers
CAS Number	76-98-2
3D model (JSmol)	Interactive image
ChEBI	CHEBI:141888
ChEMBL	ChEMBL523582
ChemSpider	19969553
PubChem CID	453209
InChI InChI=1S/C23H30N2O4/c1-5-14-8-13-11-23(22(26)29-4)20-15(6-7-25(12-13)21(14)23)16-9-18(27-2)19(28-3)10-17(16)24-20/h9-10,13-14,21,24H,5-8,11-12H2,1-4H3/t13-,14-,21-,23+/m0/s1 Key: DUFLXLVGASPEMV-BPYGGHBPSA-N
SMILES CCC1CC2CC3(C1N(C2)CCC4=C3NC5=CC(=C(C=C45)OC)OC)C(=O)OC
Properties
Chemical formula	C23H30N2O4
Molar mass	398.503 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Pharmacology

It possess central nervous system stimulant activity and produces bradycardia and hypotension in cats. It has weak acetylcholinesterase inhibitory activity and significantly increases hexobarbitone induced sleeping time.^[5]

Toxicity

It has low intravenous toxicity in mice (LD₅₀ = 143 mg/kg).^[5]

See also

• Ibogaline