CopA-like RNA

CopA-like RNA is a family of non-coding RNAs found on the R1 plasmid.

CopA-like RNA
Predicted secondary structure and sequence conservation of CopA
Identifiers
Symbol	CopA
Rfam	RF00042
Other data
RNA type	Gene; antisense
Domain(s)	Bacteria
SO	SO:0000644
PDB structures	PDBe

In several groups of bacterial plasmids, antisense RNAs regulate copy number through inhibition of replication initiator protein synthesis. These RNAs are characterised by a long hairpin structure interrupted by several unpaired nucleotides or bulged loops. In plasmid R1, the inhibitory complex between the antisense RNA (CopA) and its target mRNA (CopT) is characterised by a four-way junction structure and a side-by-side helical alignment.^[1][2][3]

See also

Plasmid-mediated resistance (sRNA section)