Corticosterone 18-monooxygenase

In enzymology, a corticosterone 18-monooxygenase (EC 1.14.15.5) is an enzyme that catalyzes the chemical reaction

corticosterone + reduced adrenal ferredoxin + O₂ ${\displaystyle \rightleftharpoons }$ 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H₂O^[1]

corticosterone 18-monooxygenase
Identifiers
EC no.	1.14.15.5
CAS no.	37256-75-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are corticosterone, reduced adrenal ferredoxin, and O₂, whereas its 3 products are 18-hydroxycorticosterone, oxidized adrenal ferredoxin, and H₂O.^[2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor.^[3][4] The systematic name of this enzyme class is corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating). Other names in common use include corticosterone 18-hydroxylase, and corticosterone methyl oxidase. This enzyme participates in c21-steroid hormone metabolism.^[5]