Costunolide synthase

Costunolide synthase (EC 1.14.13.120) is an enzyme with systematic name germacra-1(10),4,11(13)-trien-12-oate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating).^[1] This enzyme catalyses the following chemical reaction

germacra-1(10),4,11(13)-trien-12-oate + NADPH + H⁺ + O₂ ${\displaystyle \rightleftharpoons }$ (+)-costunolide + NADP⁺ + 2 H₂O

Costunolide synthase
Identifiers
EC no.	1.14.13.120
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Costunolide synthase is a heme-thiolate protein (P-450).