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Crotonyl-CoA

Chemical compound From Wikipedia, the free encyclopedia

Crotonyl-CoA
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Crotonyl-coenzyme A is an intermediate in the fermentation of butyric acid, and in the metabolism of lysine and tryptophan.[1] It is important in the metabolism of fatty acids and amino acids.[2]

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Crotonyl-CoA and reductases

Before a 2007 report by Alber and coworkers, crotonyl-CoA carboxylases and reductases (CCRs) were known for reducing crotonyl-CoA to butyryl-CoA.[3] A report by Alber and coworkers concluded that a specific CCR homolog was able to reduce crotonyl-CoA to (2S)-ethyl malonyl-CoA which was a favorable reaction.[3] The specific CCR homolog came from the bacterium Rhodobacter sphaeroides.[3]

Role of Crotonyl-CoA in Transcription

Post-translational modification of histones either by acetylation or crotonylation is important for the active transcription of genes.[4] Histone crotonylation is regulated by the concentration of crotonyl-CoA which can change based on environmental cell conditions or genetic factors.[4]

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