CtRNA

In molecular biology ctRNA (counter-transcribed RNA) is a plasmid encoded noncoding RNA that binds to the mRNA of repB and causes translational inhibition.^[1] ctRNA is encoded by plasmids and functions in rolling circle replication to maintain a low copy number. In Corynebacterium glutamicum, it achieves this by antisense pairing with the mRNA of RepB, a replication initiation protein.^[1] In Enterococcus faecium the plasmid pJB01 contains three open reading frames, copA, repB, and repC. The pJB01 ctRNA is coded on the opposite strand from the copA/repB intergenic region and partially overlaps an atypical ribosome binding site for repB.^[2]

ctRNA
Predicted secondary structure and sequence conservation of ctRNA_p42d
Identifiers
Symbol	ctRNA_p42d
Rfam	RF00489
Other data
RNA type	Gene; antisense
Domain(s)	Bacteria
SO	SO:0000644
PDB structures	PDBe

See also

• S-element