CCNC (gene)

Cyclin-C is a protein that in humans is encoded by the CCNC gene.^[5][6]

CCNC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3RGF, 4F6S, 4F6U, 4F6W, 4F70, 4F7J, 4F7L, 4F7N, 4F7S, 4G6L, 4CRL, 5HBE, 5HBH, 5BNJ, 5HBJ, 5FGK, 5CEI, 5HNB, 5HVY, 5I5Z
Identifiers
Aliases	CCNC, CycC, cyclin C, hSRB11, SRB11
External IDs	OMIM: 123838; MGI: 1858199; HomoloGene: 3803; GeneCards: CCNC; OMA:CCNC - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q16.2 Start 99,542,387 bp[1] End 99,568,825 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A3 Start 21,727,701 bp[2] End 21,759,922 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland oral cavity corpus epididymis jejunal mucosa islet of Langerhans nasal epithelium mucosa of sigmoid colon skin of thigh caput epididymis amniotic fluid Top expressed in spermatid spermatocyte ventricular zone right kidney embryo pineal gland ventral tegmental area medial vestibular nucleus genital tubercle dorsomedial hypothalamic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase regulator activity Cellular component mediator complex cyclin-dependent protein kinase holoenzyme complex nucleus nucleoplasm Biological process positive regulation of phosphorylation of RNA polymerase II C-terminal domain transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of transcription by RNA polymerase II protein phosphorylation transcription, DNA-templated regulation of cyclin-dependent protein serine/threonine kinase activity regulation of transcription by RNA polymerase II regulation of protein kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 892 51813 Ensembl ENSG00000112237 ENSMUSG00000028252 UniProt P24863 Q62447 RefSeq (mRNA) NM_001013399 NM_005190 NM_001363537 NM_001122982 NM_001290420 NM_001290422 NM_016746 RefSeq (protein) NP_001013417 NP_005181 NP_001350466 NP_001116454 NP_001277349 NP_001277351 NP_058026 Location (UCSC) Chr 6: 99.54 – 99.57 Mb Chr 4: 21.73 – 21.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phosphorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene.^[6]

Interactions

CCNC (gene) has been shown to interact with Estrogen receptor alpha^[7] and Cyclin-dependent kinase 8.^{[7][8][9][10][11]}