Cyclopregnol

Cyclopregnol (INN), also known as neurosterone, as well as 6β-hydroxy-3:5-cyclopregnan-20-one, is a synthetic pregnane steroid which was developed in the 1950s as a "psychotropic agent" for the treatment of mental disorders but was never marketed.^[1][2][3][4] Although an initial small clinical study found effectiveness,^[3] a subsequent, larger and more rigorous study found that cyclopregnol was no more effective than placebo and was clearly inferior to chlorpromazine.^[4][5]

Cyclopregnol

Clinical data
Other names	Neurosterone; 6β-Hydroxy-3:5-cyclopregnan-20-one
Identifiers
CAS Number	465-53-2
PubChem CID	12308830
ChemSpider	35517184
UNII	Z06494074X
CompTox Dashboard (EPA)	DTXSID501017011
Chemical and physical data
Formula	C21H32O2
Molar mass	316.485 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C[C@H]([C@]45[C@@]3(CC[C@H]4C5)C)O)C
InChI InChI=1S/C21H32O2/c1-12(22)15-4-5-16-14-10-18(23)21-11-13(21)6-9-20(21,3)17(14)7-8-19(15,16)2/h13-18,23H,4-11H2,1-3H3/t13-,14-,15+,16-,17-,18+,19+,20+,21+/m0/s1 Key:UGIARLNNAPRCPF-HUPPADNKSA-N

See also

• List of neurosteroids