D-Man-alpha-(1-3)-D-Glc-beta-(1-4)-D-Glc-alpha-1-diphosphoundecaprenol 2-beta-glucuronyltransferase

D-Man-alpha-(1->3) -D-Glc-beta-(1->4) -D-Glc-alpha-1-diphosphoundecaprenol 2-beta-glucuronyltransferase (EC 2.4.1.264, GumK) is an enzyme with the systematic name UDP-glucuronate: D-Man-alpha-(1->3) -D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol beta-1,2-glucuronyltransferase.^{[1][2][3][4][5][6][7]} This enzyme catalyses the following chemical reaction:

UDP-glucuronate + D-Man-alpha-(1->3) -D-Glc-beta-(1->4) -D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol ${\displaystyle \rightleftharpoons }$ UDP + D-GlcA-beta-(1->2) -D-Man-alpha-(1->3) -D-Glc-beta-(1->4) -D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol

D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphoundecaprenol 2-beta-glucuronyltransferase
Identifiers
EC no.	2.4.1.264
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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The enzyme is involved in the biosynthesis of the exopolysaccharides xanthan (in the bacterium Xanthomonas campestris) and acetan (in the bacterium Gluconacetobacter xylinus).