HCST (gene)

Hematopoietic cell signal transducer is a protein that in humans is encoded by the HCST gene.^[5][6]

HCST
Identifiers
Aliases	HCST, DAP10, KAP10, PIK3AP, hematopoietic cell signal transducer
External IDs	OMIM: 604089; MGI: 1344360; HomoloGene: 8024; GeneCards: HCST; OMA:HCST - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.12 Start 35,902,529 bp[1] End 35,904,377 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B1|7 17.45 cM Start 30,117,137 bp[2] End 30,119,279 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte bone marrow blood bone marrow cells spleen appendix lymph node thymus trabecular bone Top expressed in granulocyte thymus tibiofemoral joint blood spleen mesenteric lymph nodes embryo embryo duodenum right kidney More reference expression data BioGPS n/a
Gene ontology Molecular function signaling receptor binding protein binding phosphatidylinositol 3-kinase binding Cellular component integral component of membrane cell surface plasma membrane membrane Biological process protein phosphorylation regulation of immune response positive regulation of phosphatidylinositol 3-kinase signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10870 23900 Ensembl ENSG00000126264 ENSMUSG00000064109 UniProt Q9UBK5 Q9QUJ0 RefSeq (mRNA) NM_014266 NM_001007469 NM_011827 RefSeq (protein) NP_001007470 NP_055081 NP_035957 Location (UCSC) Chr 19: 35.9 – 35.9 Mb Chr 7: 30.12 – 30.12 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.^[6]