CLEC4A

C-type lectin domain family 4 member A is a protein that in humans is encoded by the CLEC4A gene.^[5][6]

CLEC4A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5B1W, 5B1X
Identifiers
Aliases	CLEC4A, CLECSF6, DCIR, DDB27, LLIR, CD367, HDCGC13P, C-type lectin domain family 4 member A, hDCIR
External IDs	OMIM: 605306; MGI: 1349412; HomoloGene: 49291; GeneCards: CLEC4A; OMA:CLEC4A - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 8,123,617 bp[1] End 8,138,607 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F2|6 58.18 cM Start 123,083,387 bp[2] End 123,120,958 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood appendix testicle spleen bone marrow bone marrow cells upper lobe of left lung right lung Top expressed in granulocyte stroma of bone marrow tibiofemoral joint spermatid embryo spleen Paneth cell submandibular gland seminiferous tubule blood More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane signaling receptor activity carbohydrate binding calcium ion binding mannose binding metal ion binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process cell surface receptor signaling pathway cell adhesion stimulatory C-type lectin receptor signaling pathway adaptive immune response immune system process innate immune response negative regulation of cytokine production plasmacytoid dendritic cell antigen processing and presentation negative regulation of tumor necrosis factor production CD8-positive, alpha-beta T cell activation antigen processing and presentation of exogenous peptide antigen via MHC class I Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50856 26888 Ensembl ENSG00000111729 ENSMUSG00000030148 UniProt Q9UMR7 Q9QZ15 RefSeq (mRNA) NM_016184 NM_194447 NM_194448 NM_194450 NM_001170332 NM_001170333 NM_011999 RefSeq (protein) NP_057268 NP_919429 NP_919430 NP_919432 NP_001163803 NP_001163804 NP_036129 Location (UCSC) Chr 12: 8.12 – 8.14 Mb Chr 6: 123.08 – 123.12 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response.

Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.^[6]