DEFB106A

Beta-defensin 106 is a protein that in humans is encoded by the DEFB106A gene.^[3][4]

DEFB106A
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2LWL
Identifiers
Aliases	DEFB106A, BD-6, DEFB-6, DEFB106, defensin beta 106A
External IDs	HomoloGene: 134659; GeneCards: DEFB106A; OMA:DEFB106A - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p23.1 Start 7,825,139 bp[1] End 7,829,053 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in liver cell somatic cell white blood cell monocyte blood human musculoskeletal system right lobe of liver skeletal muscle muscle of leg n/a More reference expression data BioGPS n/a
Gene ontology Molecular function lipopolysaccharide binding heparin binding protein binding CCR2 chemokine receptor binding Cellular component extracellular region nucleus cell surface extrinsic component of membrane microvesicle membrane Biological process defense response defense response to bacterium innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 245909 n/a Ensembl ENSG00000186579 ENSG00000285617 n/a UniProt Q8N104 n/a RefSeq (mRNA) NM_152251 n/a RefSeq (protein) NP_689464 n/a Location (UCSC) Chr 8: 7.83 – 7.83 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 106, DEFB106A and DEFB106B, in head-to-head orientation. This gene, DEFB106A, represents the more centromeric copy.^[4]

Function

The purified DEFB106 showed antimicrobial activity against Escherichia coli, Candida albicans and Staphylococcus aureus.^[5]