Top Qs
Timeline
Chat
Perspective
DEMPDHPCA
Pharmaceutical compound From Wikipedia, the free encyclopedia
Remove ads
DEMPDHPCA is a serotonin 5-HT2 receptor agonist and a cyclized phenethylamine and simplified or partial ergoline that is structurally related to the serotonergic psychedelic lysergic acid diethylamide (LSD).[1][2][3] It is the analogue of LSD in which the carbon and nitrogen atoms at positions 1 through 4 of the ergoline ring system have been removed.[1][2][3]
Remove ads
Pharmacology
Summarize
Perspective
DEMPDHPCA produces gross behavioral effects very similar to those of psychedelics like LSD in rodents and has been assumed to act as a hallucinogen likewise.[1] However, the drug has not been tested in humans.[1] DEMPDHPCA is much less potent than LSD in rodents, which was active at a dose of 0.16 μmol/kg by intraperitoneal injection, whereas DEMPDHPCA was active at doses of 10 to 35 μmol/kg.[1] On the other hand, DEMPDHPCA was more potent than dimethyltryptamine (DMT) and is more potent than mescaline.[1]
Like LSD, the drug has been found to act as a potent serotonin 5-HT2A and 5-HT2C receptor agonist in vitro.[2] The affinities (IC50) of the more active enantiomer are in the ranges of 10–100 nM for the serotonin 5-HT2A receptor and 100–1,000 nM for the serotonin 5-HT2C receptor, while its activational potencies (EC50) are less than 100 nM for the serotonin 5-HT2A receptor and in the range of 10–100 nM for the serotonin 5-HT2C receptor.[2] The more active enantiomer of DEIMDHPCA was among the most potent serotonin 5-HT2A receptor agonists of 27 evaluated ergoline-like compounds.[2]
Remove ads
History
DEMPDHPCA was first described in the scientific literature by Mangner in 1978.[1] It was subsequently patented in 2021 by David E. Olson and colleagues and the patent was assigned to Delix Therapeutics.[2]
Derivatives
A few derivatives of DEMPDHPCA have also been studied and found to produce similar effects and/or amphetamine-like in animals, including the derivatives with 4-methoxy- and 3,4,5-trimethoxy- substitutions on the phenyl ring and the derivative with the phenyl ring replaced with a 1-naphthalene ring.[1] The former two were less potent than DEMPDHPCA, whereas the latter was slightly more potent.[1] Another derivative of DEMPDHPCA, synthesized by David E. Nichols and described in his thesis, is DEMPDHPCA-2C-D, the derivative with 4-methyl and 2,5-dimethoxy substitutions on the phenyl ring.[4]
Chemical structures of DEMPDHPCA derivatives
DEMPDHPCA-PMA (4-methoxyphenyl-)[1]
DEMPDHPCA-mescaline (3,4,5-trimethoxyphenyl-)[1]
DEMPDHPCA-NAP (1-naphthalenyl-)[1]
DEMPDHPCA-2C-D (4-methyl-2,5-dimethoxyphenyl-)[4]
_structure.png)
See also
References
External links
Wikiwand - on
Seamless Wikipedia browsing. On steroids.
Remove ads