DIS3L

DIS3-like exonuclease 1 (Dis3L1 or Dis3L) is an enzyme that in humans is encoded by the DIS3L gene. Its protein product is an RNase enzyme homologous to the yeast protein Rrp44, and can be part of the exosome complex in the cytoplasm of eukaryotic cells.^[5][6]

DIS3L
Identifiers
Aliases	DIS3L, DIS3L1, DIS3 like exosome 3'-5' exoribonuclease
External IDs	OMIM: 614183; MGI: 2143272; HomoloGene: 15797; GeneCards: DIS3L; OMA:DIS3L - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q22.31 Start 66,293,217 bp[1] End 66,333,898 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 C Start 64,214,038 bp[2] End 64,248,570 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myocardium of left ventricle corpus callosum tibialis anterior muscle deltoid muscle vastus lateralis muscle Skeletal muscle tissue of biceps brachii muscle of thigh Achilles tendon skin of arm gonad Top expressed in spermatocyte spermatid secondary oocyte seminiferous tubule primary oocyte muscle of thigh zygote interventricular septum right kidney hand More reference expression data BioGPS n/a
Gene ontology Molecular function enzyme binding nuclease activity exonuclease activity protein binding hydrolase activity RNA binding 3'-5'-exoribonuclease activity endonuclease activity ribonuclease activity Cellular component cytoplasmic exosome (RNase complex) centrosome plasma membrane exosome (RNase complex) cytoplasm cytosol nuclear exosome (RNase complex) Biological process rRNA processing RNA phosphodiester bond hydrolysis, exonucleolytic rRNA catabolic process RNA catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 115752 213550 Ensembl ENSG00000166938 ENSMUSG00000032396 UniProt Q8TF46 Q8C0S1 RefSeq (mRNA) NM_001143688 NM_133375 NM_001323936 NM_001323937 NM_001323938 NM_001323939 NM_001323940 NM_001323941 NM_001323943 NM_001323944 NM_001323945 NM_001323946 NM_001323948 NM_001001295 NM_001177784 NM_172519 RefSeq (protein) NP_001137160 NP_001310865 NP_001310866 NP_001310867 NP_001310868 NP_001310869 NP_001310870 NP_001310872 NP_001310873 NP_001310874 NP_001310875 NP_001310877 NP_588616 NP_001001295 NP_001171255 NP_766107 Location (UCSC) Chr 15: 66.29 – 66.33 Mb Chr 9: 64.21 – 64.25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse