DNA-3-methyladenine glycosylase II

DNA-3-methyladenine glycosylase II (EC 3.2.2.21) is an enzyme^[1][2][3][4] that catalyses the following chemical reaction:

Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine, and 7-methyladenine

DNA-3-methyladenine glycosylase II
Identifiers
EC no.	3.2.2.21
CAS no.	89287-38-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Involved in the removal of alkylated bases from DNA in Escherichia coli.

Evolution

Through the process of convergent evolution, there are at least two unrelated protein folds that share the same DNA-3-methyladenine glycosylase activity. The first, the AlkA N-terminal domain, is found in bacteria Pfam PF06029. The second, methylpurine-DNA glycosylase (MPG) Pfam PF02245 is found in vertebrates including humans.^[5]

Nomenclature

DNA-3-methyladenine glycosylase II is also known as

• deoxyribonucleate 3-methyladenine glycosides II
• 3-methyladenine DNA glycosylase II
• DNA-3-methyladenine glycosides II
• AlkA
• alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)

See also

• MAG1 (DNA-3-methyladenine glycosylase)