DNA-formamidopyrimidine glycosylase

DNA-formamidopyrimidine glycosylase (EC 3.2.2.23, Fapy-DNA glycosylase, deoxyribonucleate glycosidase, 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase, 2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase, formamidopyrimidine-DNA glycosylase, DNA-formamidopyrimidine glycosidase, Fpg protein) is an enzyme with systematic name DNA glycohydrolase (2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing).^[1] FPG is a base excision repair enzyme which recognizes and removes a wide range of oxidized purines from correspondingly damaged DNA.^[2] It was discovered by Zimbabwean scientist Christopher J. Chetsanga in 1975.^[3]

DNA-formamidopyrimidine glycosylase
Identifiers
EC no.	3.2.2.23
CAS no.	78783-53-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme catalyses the following chemical reaction

Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine

This enzyme participates in processes leading to recovery from mutagenesis and/or cell death by alkylating agents.