Dipeptidase 2

Dipeptidase 2 (DPEP2) is a protein which in humans is encoded by the DPEP2 gene.^[4]

DPEP2
Identifiers
Aliases	DPEP2, MBD2, dipeptidase 2
External IDs	OMIM: 609925; MGI: 2442042; HomoloGene: 49703; GeneCards: DPEP2; OMA:DPEP2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 67,987,394 bp[1] End 68,000,586 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood spleen right lung lymph node bone marrow upper lobe of left lung testicle appendix n/a More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activity metalloexopeptidase activity dipeptidyl-peptidase activity metallopeptidase activity hydrolase activity metal ion binding dipeptidase activity Cellular component anchored component of membrane membrane Biological process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64174 319446 Ensembl ENSG00000167261 ENSMUSG00000053687 UniProt Q9H4A9 Q8C255 RefSeq (mRNA) NM_022355 NM_001324159 NM_001369657 NM_001301204 NM_001301205 NM_176913 RefSeq (protein) NP_001311088 NP_071750 NP_001356586 NP_001288133 NP_001288134 NP_795887 Location (UCSC) Chr 16: 67.99 – 68 Mb n/a PubMed search [2] [3]
Wikidata
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DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D₄, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation.^[5]