Denaverine

Denaverine is an antispasmodic drug. It was developed in Germany and patented in 1974. Denaverine hydrochloride is used in veterinary medicine under the trade name Sensiblex as a muscle relaxant for the myometrium of cows and dogs during parturition.^[1] Under the trade name Spasmalgan, it has also been used in humans for the treatment of urogenital and gastrointestinal spasms.^[2]

Denaverine

Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy category	Gr 1 (Germany)
Routes of administration	intramuscular injection, suppositories
ATCvet code	QG02CX90 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	8% (suppositories), 37% (oral solution)
Metabolism	mainly hepatic, at least 11 metabolites
Elimination half-life	34 hours
Identifiers
IUPAC name 2-(Dimethylamino)ethyl (2-ethylbutoxy)diphenylacetate
CAS Number	3579-62-2 Y 3321-06-0 (hydrochloride)
PubChem CID	71130
ChemSpider	64278 N
UNII	O14NF38MTL
KEGG	D07787 Y
ChEMBL	ChEMBL1614656 N
CompTox Dashboard (EPA)	DTXSID10189315
Chemical and physical data
Formula	C24H33NO3
Molar mass	383.532 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCC(CC)COC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)OCCN(C)C
InChI InChI=1S/C24H33NO3/c1-5-20(6-2)19-28-24(21-13-9-7-10-14-21,22-15-11-8-12-16-22)23(26)27-18-17-25(3)4/h7-16,20H,5-6,17-19H2,1-4H3 N Key:FPTOUQZVCUIPHY-UHFFFAOYSA-N N
NY (what is this?)  (verify)

Mechanism of action

Denaverine, like papaverine, acts as a phosphodiesterase inhibitor. Additionally, it has anticholinergic effects.^[3]