Dermatopathic lymphadenopathy

In pathology, dermatopathic lymphadenopathy, is lymph node pathology due to skin disease.

Dermatopathic lymphadenopathy
Other names	Dermatopathic lymphadenitis
Micrograph showing dermatopathic lymphadenopathy with the characteristic paracortical histiocytosis and melanin-laden macrophages. H&E stain.
Specialty	Dermatology

Cause

Also known as lipomelanotic reticulosis or Pautrier-Woringer disease, represents a rare form of benign lymphatic hyperplasia associated with most exfoliative or eczematoid inflammatory erythrodermas, including pemphigus, psoriasis, eczema, neurodermatitis, and atrophia senilis.

Diagnosis

Dermatopathic lymphadenopathy is diagnosed by a lymph node biopsy. It has a characteristic pattern of histomorphology and immunohistochemical staining:

• Paracortical histiocytosis
• Melanin-laden macrophages
• Eosinophils
• Plasma cells (medulla of lymph node)

Differential diagnosis

• Cutaneous T cell lymphoma^[1]
• Hodgkin's lymphoma^[1]
• Melanoma

Treatment

The treatment is based on the underlying cause.

See also

• Skin disease
• List of cutaneous conditions