Desidustat

Desidustat (INN, also known as ZYAN1) is a drug for the treatment of anemia of chronic kidney disease. This drug with the brand name Oxemia is discovered and developed by Zydus Life Sciences.^[1]

Desidustat

Clinical data
Other names	ZYAN1
Identifiers
IUPAC name 2-{{#parsoidfragment:2}}1-(Cyclopropylmethoxy)-4-hydroxy-2-oxoquinoline-3-carbonyl]amino]acetic acid
CAS Number	1616690-16-4
PubChem CID	75593290
DrugBank	DB16135
ChemSpider	64835241
UNII	Y962PQA4KS
ChEBI	CHEBI:230352
ChEMBL	ChEMBL4650314
Chemical and physical data
Formula	C16H16N2O6
Molar mass	332.312 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1CC1CON2C3=CC=CC=C3C(=C(C2=O)C(=O)NCC(=O)O)O
InChI InChI=1S/C16H16N2O6/c19-12(20)7-17-15(22)13-14(21)10-3-1-2-4-11(10)18(16(13)23)24-8-9-5-6-9/h1-4,9,21H,5-8H2,(H,17,22)(H,19,20) Key:IKRKQQLJYBAPQT-UHFFFAOYSA-N

Mechanism of action

Desidustat reduces the requirement of recombinant erythropoietin (EPO) in anemia, and decreases EPO-resistance, by reducing IL-6, IL-1β, and anti-EPO antibodies.^[2]

Clinical Trials

Clinical trials on desidustat have been done in India and Australia.^[3]

Potential additional indications

Desidustat has been studied for use in conditions beyond anemia of chronic kidney disease, including chemotherapy-induced anemia, inflammation-induced anemia, and acute kidney injury. It is also being evaluated in clinical trials for sickle cell disease and has been suggested as a treatment for complement-mediated diseases and stroke in chronic kidney disease patients.^[4]

Society and culture

Regulatory approvals

The subject expert committee of CDSCO has recommended the grant of permission for manufacturing and marketing of Desidustat 25 mg and 50 mg tablets in India, based on some conditions related to package insert, phase 4 protocols, prescription details, and GCP.^[5]

Market and commercialization

Zydus Lifesciences and Sun Pharmaceuticals have entered an agreement in October 2023 to co-market Desidustat. Sun Pharma will sell the drug as Rytstat, while Zydus will continue to sell it as Oxemia.^[6]