Deudomperidone

Deudomperidone (developmental code name CIN-102; also known as deuterated domperidone) is a dopamine antagonist medication which is under development in the United States for the treatment of gastroparesis.^[1][2][3] It acts as a selective dopamine D₂ and D₃ receptor antagonist and has peripheral selectivity.^[2][3] Deudomperidone is a deuterated form of domperidone, and it is suggested that deudomperidone may have improved efficacy, tolerability, and pharmacokinetics compared to domperidone.^[2][3] As of January 2022, deudomperidone is in phase 2 clinical trials for the treatment of gastroparesis.^[1]

Deudomperidone

Clinical data
Other names	CIN-102; deuterated domperidone; domperidone deuterated
Identifiers
IUPAC name 3-[3-[4-(5-chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propyl]-4,5,6,7-tetradeuterio-1H-benzimidazol-2-one
CAS Number	2121525-08-2 Y
PubChem CID	153420471
ChemSpider	58794254
UNII	HN0VIB0W8W
KEGG	D11864
ChEMBL	ChEMBL4594380
Chemical and physical data
Formula	C22H20ClD4N5O2
Molar mass	429.94 g·mol−1
3D model (JSmol)	Interactive image
SMILES [2H]C1=C(C(=C2C(=C1[2H])NC(=O)N2CCCN3CCC(CC3)N4C5=C(C=C(C=C5)Cl)NC4=O)[2H])[2H]
InChI InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)/i1D,2D,4D,5D Key:FGXWKSZFVQUSTL-GYABSUSNSA-N

See also

• Metopimazine
• Trazpiroben