Dexloxiglumide

Dexloxiglumide is a drug which acts as a cholecystokinin antagonist, selective for the CCK_A subtype. It inhibits gastrointestinal motility and reduces gastric secretions, and despite older selective CCK_A antagonists such as lorglumide and devazepide having had only limited success in trials and ultimately never making it into clinical use, dexloxiglumide is being investigated as a potential treatment for a variety of gastrointestinal problems including irritable bowel syndrome,^[1] dyspepsia,^[2] constipation^[3] and pancreatitis,^[4][5] and has had moderate success so far although trials are still ongoing.

Dexloxiglumide

Clinical data
ATC code	none
Identifiers
IUPAC name (4R)-4-[(3,4-dichlorobenzoyl)amino]-5-(3-methoxypropylpentylamino)-5-oxopentanoic acid
CAS Number	119817-90-2 Y
PubChem CID	65937
IUPHAR/BPS	889
ChemSpider	59342 N
UNII	69DY40RH9B
ChEMBL	ChEMBL550781 N
CompTox Dashboard (EPA)	DTXSID50152604
Chemical and physical data
Formula	C21H30Cl2N2O5
Molar mass	461.38 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCCN(CCCOC)C(=O)[C@@H](CCC(=O)O)NC(=O)C1=CC(=C(C=C1)Cl)Cl
InChI InChI=1S/C21H30Cl2N2O5/c1-3-4-5-11-25(12-6-13-30-2)21(29)18(9-10-19(26)27)24-20(28)15-7-8-16(22)17(23)14-15/h7-8,14,18H,3-6,9-13H2,1-2H3,(H,24,28)(H,26,27)/t18-/m1/s1 N Key:QNQZBKQEIFTHFZ-GOSISDBHSA-N N
NY (what is this?)  (verify)