Diadenosine hexaphosphate hydrolase (AMP-forming)

Diadenosine hexaphosphate hydrolase (AMP-forming) (EC 3.6.1.60, hAps1, NUDT11 (gene), hAps2, NUDT10 (gene)) is an enzyme with systematic name P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (AMP-forming).^[1][2] This enzyme catalyses the following chemical reaction

(1) P1,P6-bis(5'-adenosyl)hexaphosphate + H₂O ${\displaystyle \rightleftharpoons }$ adenosine 5'-pentaphosphate + AMP

(2) P1,P5-bis(5'-adenosyl)pentaphosphate + H₂O ${\displaystyle \rightleftharpoons }$ adenosine 5'-tetraphosphate + AMP

Diadenosine hexaphosphate hydrolase (AMP-forming)
Identifiers
EC no.	3.6.1.60
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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A divalent cation is essential for activity.