Diadenosine hexaphosphate hydrolase (ATP-forming)

Diadenosine hexaphosphate hydrolase (ATP-forming) (EC 3.6.1.61, Ndx1) is an enzyme with systematic name P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (ATP-forming).^[1] This enzyme catalyses the following chemical reaction

(1) P1,P6-bis(5'-adenosyl)hexaphosphate + H₂O ${\displaystyle \rightleftharpoons }$ 2 ATP

(2) P1,P5-bis(5'-adenosyl)pentaphosphate + H₂O ${\displaystyle \rightleftharpoons }$ ATP + ADP

(3) P1,P4-bis(5'-adenosyl)tetraphosphate + H₂O ${\displaystyle \rightleftharpoons }$ ATP + AMP

Diadenosine hexaphosphate hydrolase (ATP-forming)
Identifiers
EC no.	3.6.1.61
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

The enzyme requires the presence of the divalent cations (Mn²⁺, Mg²⁺, Zn²⁺, and Co²⁺).