Dibekacin

Dibekacin (3',4'-dideoxykanamycin B) is an aminoglycoside antibiotic. It is a semisynthetic derivative of kanamycin developed by Hamao Umezawa and collaborators for Meiji Seika.^[1][2]

Dibekacin

Clinical data
Trade names	Panimycin, Tokocin
Other names	3',4'-Dideoxykanamycin B
AHFS/Drugs.com	International Drug Names
ATC code	J01GB09 (WHO) S01AA29 (WHO)
Identifiers
IUPAC name (2S,3R,4S,5S,6R)-4-Amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,6S)-3-amino-6-(aminomethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol
CAS Number	34493-98-6
PubChem CID	470999
ChemSpider	413666
UNII	45ZFO9E525
KEGG	D07811
ChEMBL	ChEMBL560976
PDB ligand	84D (PDBe, RCSB PDB)
CompTox Dashboard (EPA)	DTXSID2022915
ECHA InfoCard	100.047.316
Chemical and physical data
Formula	C18H37N5O8
Molar mass	451.521 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1C[C@H]([C@H](O[C@@H]1CN)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)N)O)N)N)N
InChI InChI=1S/C18H37N5O8/c19-4-6-1-2-7(20)17(28-6)30-15-8(21)3-9(22)16(14(15)27)31-18-13(26)11(23)12(25)10(5-24)29-18/h6-18,24-27H,1-5,19-23H2/t6-,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1 Key:JJCQSGDBDPYCEO-XVZSLQNASA-N

It has been used in combination with sulbenicillin.^[3]