Dibunate

Dibunate is a cough suppressant.^[1] As the sodium salt, it has been marketed under the name Becantyl (in the United Kingdom), Becantex (in continental Europe), or Linctussal with a dosage of 20 to 30 mg, as either syrup or tablets.^[2]

Dibunate

Clinical data
Trade names	Aducin, Becantal, Becantex, Bechisan, Bexedyl, Keuten, Linctussal, Pectoro
ATC code	R05DB16 (WHO)
Identifiers
IUPAC name 2,6-Di-tert-butylnaphthalene-1-sulfonic acid
CAS Number	14992-58-6
PubChem CID	84746
DrugBank	DB13796 Y
ChemSpider	76450 Y
UNII	ZXY319VL5S
KEGG	D01700
ChEBI	CHEBI:145567
ChEMBL	ChEMBL1865134
CompTox Dashboard (EPA)	DTXSID7048245
ECHA InfoCard	100.035.511
Chemical and physical data
Formula	C18H24O3S
Molar mass	320.45 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=S(=O)(O)c1c2c(ccc1C(C)(C)C)cc(cc2)C(C)(C)C
InChI InChI=1S/C18H24O3S/c1-17(2,3)13-8-9-14-12(11-13)7-10-15(18(4,5)6)16(14)22(19,20)21/h7-11H,1-6H3,(H,19,20,21) Y Key:WBEBQCINXJDZCX-UHFFFAOYSA-N Y
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Similar to benzonatate, it is a peripherally acting drug. It has not been reported to cause sedation, euphoria, habituation, or respiratory depression, unlike narcotic antitussives such as codeine. It may work by blocking afferent signals in the reflex arc which controls cough.^[3] Nausea is rarely seen as an adverse effect.^[4]