Difluprednate

Difluprednate, sold under the brand name Durezol, is a corticosteroid used for the treatment of post-operative ocular inflammation and pain.^[1]

Difluprednate

Clinical data
Trade names	Durezol
AHFS/Drugs.com	Monograph
MedlinePlus	a609025
License data	US FDA: Difluprednate
Routes of administration	Eye drops
ATC code	D07AC19 (WHO) S01BA16 (WHO)
Legal status
Legal status	US: ℞-only[1]
Identifiers
IUPAC name [(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] butanoate
CAS Number	23674-86-4 Y
PubChem CID	32037
DrugBank	DB06781 N
ChemSpider	391990 N
UNII	S8A06QG2QE
KEGG	D01266 Y
ChEBI	CHEBI:31485
ChEMBL	ChEMBL1201749 N
CompTox Dashboard (EPA)	DTXSID0046773
ECHA InfoCard	100.041.636
Chemical and physical data
Formula	C27H34F2O7
Molar mass	508.559 g·mol−1
3D model (JSmol)	Interactive image
SMILES [H][C@@]12CC[C@](OC(=O)CCC)(C(=O)COC(C)=O)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C
InChI InChI=1S/C27H34F2O7/c1-5-6-23(34)36-26(22(33)14-35-15(2)30)10-8-17-18-12-20(28)19-11-16(31)7-9-24(19,3)27(18,29)21(32)13-25(17,26)4/h7,9,11,17-18,20-21,32H,5-6,8,10,12-14H2,1-4H3/t17-,18-,20-,21-,24-,25-,26-,27-/m0/s1 Key:WYQPLTPSGFELIB-JTQPXKBDSA-N
NY (what is this?)  (verify)

It was approved for medical use in the United States in June 2008.^[1][2][3] It is available as a generic medication.^[4]

Medical uses

Difluprednate is indicated for the treatment of inflammation and pain associated with ocular surgery; and the treatment of endogenous anterior uveitis.^[1]

Clinical trials

Difluprednate ophthalmic emulsion 0.05% is also being studied in other ocular inflammatory diseases, including a phase 3 study evaluating difluprednate for the treatment of anterior uveitis^[5][6]