Dihydroisocodeine

Chemical compound From Wikipedia, the free encyclopedia

Dihydroisocodeine

Dihydroisocodeine is an opioid.[1] The National Research Council of the United States reported in 1941 that isocodeine is one of four isomers of codeine known at the time (heterocodeine can be considered a fifth) and DHIC, then in use in Europe as a pharmaceutical, was four times stronger than dihydrocodeine as isocodeine is four times stronger than codeine. The other isomers of codeine are allocodeine and pseudocodeine and they are active drugs as is heterocodeine, which is estimated to be up to 108 times as potent as codeine. [2]

Quick Facts Names, Identifiers ...
Dihydroisocodeine
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Names
IUPAC name
3-Methoxy-17-methyl-4,5α-epoxymorphinan-6β-ol
Systematic IUPAC name
(4R,4aR,7R,7aR,12bS)-9-Methoxy-3-methyl-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methano[1]benzofuro[3,2-e]isoquinolin-7-ol
Other names
DHIC
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C18H23NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3,6,11-13,17,20H,4-5,7-9H2,1-2H3/t11-,12+,13+,17-,18-/m0/s1
    Key: RBOXVHNMENFORY-KEMUOJQUSA-N
  • CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3[C@@H](CC4)O
Properties
C18H23NO3
Molar mass 301.386 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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References

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