Dimethylmalate dehydrogenase

In enzymology, dimethylmalate dehydrogenase (EC 1.1.1.84) is an enzyme that catalyzes the chemical reaction

(R)-3,3-dimethylmalic acid

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

α-Ketoisovaleric acid

+ CO₂ + NADH

 

dimethylmalate dehydrogenase
Identifiers
EC no.	1.1.1.84
CAS no.	37250-21-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The two substrates of this enzyme are (R)-3,3-dimethylmalic acid and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are α-ketoisovaleric acid, carbon dioxide, reduced NADH, and a proton.^[1][2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-3,3-dimethylmalate:NAD⁺ oxidoreductase (decarboxylating). This enzyme is also called beta,beta-dimethylmalate dehydrogenase. This enzyme participates in pantothenate and coa biosynthesis. It has 5 cofactors: ammonia, manganese, cobalt, potassium, and NH₄⁺.