Dinovernavirus

Dinovernavirus is a genus of double-stranded RNA viruses in the order Reovirales and family Spinareoviridae. Member viruses replicate in a variety of mosquito cell lines. The name is an abbreviation for double-stranded, insect, novem (Latin for nine the number of genome segments), rna virus. There is one species in the genus: Aedes pseudoscutellaris reovirus (Dinovernavirus aedis).^[1][2]

Dinovernavirus
Cryo-EM reconstruction of Fako virus capsid showing: turret protein (red), clamp protein (yellow), and homodimer of major capsid protein (blue/purple)
Virus classification
(unranked):	Virus
Realm:	Riboviria
Kingdom:	Orthornavirae
Phylum:	Duplornaviricota
Class:	Resentoviricetes
Order:	Reovirales
Family:	Spinareoviridae
Genus:	Dinovernavirus

Structure

Viruses in Dinovernavirus are non-enveloped. Their capsid is turreted and single shelled with icosahedral geometries and T=2 symmetry. The diameter is around 49–50 nm.^[1]

Genome

Genomes are linear and segmented. There are nine segments which code for nine proteins.^[1]

Life cycle

Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment to host receptors, which mediates endocytosis. Replication follows the double-stranded RNA virus replication model. Double-stranded RNA virus transcription is the method of transcription. The virus exits the host cell by monopartite non-tubule guided viral movement. Mosquito serve as the natural host.^[1]