Dioxethedrin

Not to be confused with Dioxifedrine.

Dioxethedrin (INNTooltip International Nonproprietary Name), or dioxethedrine, also known as 3,4-dihydroxy-N-ethylnorephedrine, is a sympathomimetic medication.^[1][2][3] It was a component of the antitussive syrup Bexol (a combination of dioxethedrin, codeine, and promethazine).^[4][5] It is an ephedrine derivative (and hence is a phenethylamine and amphetamine) and is described as a bronchodilator and β-adrenergic receptor agonist.^[2][4] Analogues of dioxethedrin include dioxifedrine (α-methylepinephrine; 3,4-dihydroxyephedrine), corbadrine (levonordefrin; α-methylnorepinephrine), and α-methyldopamine.^[1]

Dioxethedrin

Clinical data
Other names	Dioxethedrine; 3,4-Dihydroxy-N-ethylnorephedrine; 3,4,β-Trihydroxy-N-ethyl-α-methyl-β-phenethylamine; 3,4,β-Trihydroxy-N-ethylamphetamine; α-Methyl-N-ethylnorepinephrine
Identifiers
IUPAC name 4-[2-(ethylamino)-1-hydroxypropyl]benzene-1,2-diol
CAS Number	497-75-6
PubChem CID	71632
ChemSpider	64697
UNII	82J92E653W
ChEBI	CHEBI:134881
ChEMBL	ChEMBL2110629
CompTox Dashboard (EPA)	DTXSID00862044
ECHA InfoCard	100.007.137
Chemical and physical data
Formula	C11H17NO3
Molar mass	211.261 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCNC(C)C(C1=CC(=C(C=C1)O)O)O
InChI InChI=1S/C11H17NO3/c1-3-12-7(2)11(15)8-4-5-9(13)10(14)6-8/h4-7,11-15H,3H2,1-2H3 Key:OHDICGSRVLBVLC-UHFFFAOYSA-N