Diphenpipenol

Diphenpipenol is an opioid analgesic drug invented in the 1970s by Dainippon Pharmaceutical Co.^[1] It is chemically a 1-substituted-4-(1,2-diphenylethyl)piperazine derivative related to compounds such as MT-45 and AD-1211, but diphenpipenol is the most potent compound in the series, with the more active (S) enantiomer being around 105 times the potency of morphine in animal studies.^[2] This makes it a similar strength to fentanyl and its analogues, and consequently diphenpipenol can be expected to pose a significant risk of producing life-threatening respiratory depression, as well as other typical opioid side effects such as sedation, itching, nausea and vomiting.

Diphenpipenol

Clinical data
ATC code	None
Identifiers
IUPAC name 3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylethyl]phenol
CAS Number	83374-54-3 Y
PubChem CID	13236269
ChemSpider	15325002
UNII	ZK4VB64WSR
ChEMBL	ChEMBL1189795
CompTox Dashboard (EPA)	DTXSID901336845
Chemical and physical data
Formula	C25H28N2O2
Molar mass	388.511 g·mol−1
3D model (JSmol)	Interactive image
SMILES COc4ccccc4N1CCN(CC1)C(Cc2cccc(O)c2)c3ccccc3
InChI InChI=1S/C25H28N2O2/c1-29-25-13-6-5-12-23(25)26-14-16-27(17-15-26)24(21-9-3-2-4-10-21)19-20-8-7-11-22(28)18-20/h2-13,18,24,28H,14-17,19H2,1H3 Key:ILCZMFSACNEMGK-UHFFFAOYSA-N

Diphenpipenol has been offered for sale online as a designer drug, though analysis of a sample of supposed diphenpipenol found it to instead contain a structural isomer with much weaker opioid activity, and it is unclear if genuine diphenpipenol has actually been sold.^[3]

Alternate isomer sold as diphenpipenol

See also

• 3C-PEP
• Azaprocin
• Bucinnazine
• Diphenidine
• Lefetamine