Dedicator of cytokinesis protein 5

Dedicator of cytokinesis protein 5 (Dock5) is a large (~180 kDa) protein encoded in the human by the DOCK5 gene, involved in intracellular signalling networks.^[5] It is a member of the DOCK-A subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which function as activators of small G-proteins.^[6] Dock5 is predicted to activate the small G protein Rac.

DOCK5
Identifiers
Aliases	DOCK5, Dock5, dedicator of cytokinesis 5
External IDs	OMIM: 616904; MGI: 2652871; HomoloGene: 57016; GeneCards: DOCK5; OMA:DOCK5 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.2 Start 25,184,689 bp[1] End 25,418,082 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D1 Start 67,989,584 bp[2] End 68,170,891 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum sural nerve corpus callosum inferior ganglion of vagus nerve blood pons germinal epithelium internal globus pallidus subthalamic nucleus pancreatic epithelial cell Top expressed in epithelium of lens granulocyte secondary oocyte zygote gastrula ciliary body Ileal epithelium retinal pigment epithelium primary oocyte decidua More reference expression data BioGPS n/a
Gene ontology Molecular function guanyl-nucleotide exchange factor activity protein binding GTPase activator activity Cellular component plasma membrane membrane cytoplasm cytosol Biological process small GTPase mediated signal transduction negative regulation of vascular associated smooth muscle contraction positive regulation of vascular associated smooth muscle cell migration positive regulation of substrate adhesion-dependent cell spreading positive regulation of epithelial cell migration cell migration positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80005 68813 Ensembl ENSG00000147459 ENSMUSG00000044447 UniProt Q9H7D0 B2RY04 RefSeq (mRNA) NM_024940 NM_001322810 NM_177780 RefSeq (protein) NP_001309739 NP_079216 NP_808448 Location (UCSC) Chr 8: 25.18 – 25.42 Mb Chr 14: 67.99 – 68.17 Mb PubMed search [3] [4]
Wikidata
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Function

Dock5 shares significant sequence identity with Dock180, the archetypal member of the DOCK family. It is therefore predicted to partake in similar interactions although this has yet to be demonstrated. Indeed, the function and signalling properties of Dock5 are poorly understood thus far. Dock5 has been identified as a crucial signalling protein in osteoclasts,^[7] and suppression of Dock5 expression with shRNA has been shown to inhibit survival and differentiation of osteoclast precursor cells.^[8] In addition, a mutation in Dock5 has been associated with the rupture of murine lens cataracts.^[9] In zebrafish Dock5 has been implicated in myoblast fusion.^[10]