Doramectin

Doramectin, sold under the brand name Dectomax among others, is a veterinary medication approved by the US Food and Drug Administration (FDA) for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice, and mange mites in cattle.^[1][2] It is available as a generic medication.^[3] It is available as a combination with levamisole under the brand name Valcor.^[4]

Doramectin

Clinical data
Trade names	Dectomax, others
Other names	25-cyclohexylavermectin B1, 25-cyclohexyl-25-de(l-methylpropyl)avermectin B1a, 25-cyclohexyl-5-O-demethyl-25-de(l-methylpropyl)avermectin A1a
AHFS/Drugs.com	International Drug Names
License data	US DailyMed: Doramectin
Routes of administration	Subcutaneous, intramuscular, topical
ATCvet code	QP54AA03 (WHO)
Legal status
Legal status	US: OTC for animals[1][2][3]
Identifiers
IUPAC name (1'R,2S,4'S,5S,6R,8'R,10'E,12'R,13'S,14'E,20'R,21'R,24'S)-6-cyclohexyl-21',24'-dihydroxy-12'-{[(2R,4S,5S,6S)-5-{[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-4-methoxy-6-methyloxan-2-yl]oxy}-5,11',13',22'-tetramethyl-5,6-dihydro-3',7',19'-trioxaspiro[pyran-2,6'-tetracyclo[15.6.1.14,8.020,24]pentacosane]-10',14',16',22'-tetraen-2'-one
CAS Number	117704-25-3 Y
PubChem CID	9832750
ChemSpider	8008478 Y
UNII	KGD7A54H5P
KEGG	D01129 Y
CompTox Dashboard (EPA)	DTXSID9048982
ECHA InfoCard	100.123.125
Chemical and physical data
Formula	C50H74O14
Molar mass	899.128 g·mol−1
InChI InChI=1S/C50H74O14/c1-27-13-12-16-34-26-57-47-42(51)30(4)21-37(50(34,47)54)48(53)60-36-22-35(63-49(25-36)20-19-29(3)45(64-49)33-14-10-9-11-15-33)18-17-28(2)44(27)61-41-24-39(56-8)46(32(6)59-41)62-40-23-38(55-7)43(52)31(5)58-40/h12-13,16-17,19-21,27,29,31-33,35-47,51-52,54H,9-11,14-15,18,22-26H2,1-8H3/b13-12+,28-17+,34-16+/t27-,29-,31-,32-,35+,36-,37-,38-,39-,40-,41-,42+,43-,44-,45-,46-,47+,49+,50+/m0/s1 Y Key:QLFZZSKTJWDQOS-YDBLARSUSA-N Y
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It is used for the treatment and control of internal parasitosis (gastrointestinal and pulmonary nematodes), ticks and mange (and other ectoparasites). Doramectin is a derivative of avermectin. Similarly to other drugs of this family, it is produced by fermentation by selected strains of Streptomyces avermitilis followed by chemical modification.^[1][2][5] Its spectrum includes: Haemonchus, Ostertagia, Trichostrongylus, Cooperia, and Oesophagostomum species and Dictyocaulus viviparus, Dermatobia hominis, Boophilus microplus, and Psoroptes bovis, among many other internal and external parasites. It is available as an injection and as a topical solution.^[1][2]

Society and culture

Legal status

In November 2024, the FDA approved doramectin (brand name Doracide) for the treatment and control of gastrointestinal roundworms, lungworms, eyeworms, grubs, biting and sucking lice, horn flies, and mange mites in cattle.^[6][7]

Brand names

Doramectin is marketed under the brand name Doramec L.A. for cattle, sheep, and swine.^{[citation needed]}

Doramectin is available for horses as an oral, flavored, bioadhesive gel under the name Doraquest L.A. Oral Gel. It can be used to control and treat internal parasites as roundworms, lungworms and some external parasites.^{[citation needed]}