Chloride anion exchanger

Chloride anion exchanger, also known as down-regulated in adenoma (protein DRA), is a protein that in humans is encoded by the SLC26A3 gene.^[5]

SLC26A3
Identifiers
Aliases	SLC26A3, CLD, DRA, solute carrier family 26 member 3
External IDs	OMIM: 126650; MGI: 107181; HomoloGene: 55435; GeneCards: SLC26A3; OMA:SLC26A3 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.3-q31.1 Start 107,765,467 bp[1] End 107,803,225 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 A2|12 13.45 cM Start 31,440,870 bp[2] End 31,523,916 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of colon mucosa of sigmoid colon rectum mucosa of transverse colon seminal vesicula mucosa of ileum jejunal mucosa duodenum appendix corpus epididymis Top expressed in left colon epithelium of small intestine duodenum seminal vesicula ileum jejunum Paneth cell efferent ductule migratory enteric neural crest cell cecum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chloride transmembrane transporter activity transporter activity DNA-binding transcription factor activity transcription coregulator activity sulfate transmembrane transporter activity secondary active sulfate transmembrane transporter activity bicarbonate transmembrane transporter activity oxalate transmembrane transporter activity protein binding antiporter activity chloride channel activity inorganic anion exchanger activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane brush border membrane apical plasma membrane sperm midpiece Biological process excretion intracellular pH elevation membrane hyperpolarization sulfate transport regulation of membrane potential regulation of intracellular pH ion transport anion transport bicarbonate transport sperm capacitation chloride transport cellular response to cAMP regulation of transcription, DNA-templated chloride transmembrane transport oxalate transport sulfate transmembrane transport transmembrane transport regulation of nucleic acid-templated transcription anion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1811 13487 Ensembl ENSG00000091138 ENSMUSG00000001225 UniProt P40879 Q9WVC8 RefSeq (mRNA) NM_000111 NM_021353 RefSeq (protein) NP_000102 NP_067328 Location (UCSC) Chr 7: 107.77 – 107.8 Mb Chr 12: 31.44 – 31.52 Mb PubMed search [3] [4]
Wikidata
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Function

Protein DRA is a membrane protein in intestinal cells. It is an anion exchanger and a member of the sulfate anion transporter (SAT) family. It mediates chloride and bicarbonate exchange and additionally transports sulfate and other anions at the apical membrane, part of the plasma membrane of enterocytes. It is different from the anion exchanger that present in erythrocytes, renal tubule, and several other tissues.^[6]

The protein encoded by this gene is a transmembrane glycoprotein that functions as a sulfate transporter. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells, and is instrumental in chloride reuptake, aiding in the creation of an osmotic gradient for resorption of fluid from the lumen of the intestine.^[7]

Clinical significance

Mutations in this gene have been associated with congenital chloride diarrhoea,^[5] a treatable disease.

The congenital absence of this membrane protein results in an autosomal recessive disorder called congenital chloridorrhea or congenital chloride diarrhea (CLD).^[8]

See also

• Solute carrier family