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Drozitumab
Monoclonal antibody From Wikipedia, the free encyclopedia
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Drozitumab is a human monoclonal antibody in development for the treatment of cancers.[1][2] It targets Tumour Necrosis Factor Related Apoptosis-inducing Ligand (TRAIL), whose receptors are found on the surface of many types of malignant cells.[3][4] Drozitumab was developed by Genentech.
Although drozitumab was studied in phase II trials for treating chondrosarcoma, colorectal cancer, non-Hodgkin lymphoma, and non-small cell lung cancer, development has been halted due to lack of clinical response.[3]
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