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E. coli nitroreductase
Microbial protein found in Escherichia coli str. K-12 substr. MG1655 From Wikipedia, the free encyclopedia
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E. coli nitroreductase is a flavoprotein found in the bacteria Escherichia coli. It catalyses the reduction of nitro groups in a wide range of substrates to produce the corresponding hydroxylamine. Although its role in vivo is unclear, it has been identified as useful in the metabolism of a number of prodrugs in anti-cancer gene therapy.[1]
 | This article relies largely or entirely on a single source. (July 2023) |
There are at least two oxygen-insensitive nitroreductases in E. coli. The major one is NfsA (P17117, EC 1.7.1.B3).[2] The other is NfsB (P38489, EC 1.5.1.34).[3]
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