Endothelin converting enzyme 1

Endothelin converting enzyme 1, also known as ECE1, is an enzyme which in humans is encoded by the ECE1 gene.^[5][6][7] It is inhibited by phosphoramidon.^[8] ECE1 also mediates melanin production through breaking down inactive Big-EDN1 to produce an active EDN1 in keratinocytes and endothelial cells. ^[9]

ECE1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3DWB
Identifiers
Aliases	ECE1, ECE, endothelin converting enzyme 1
External IDs	OMIM: 600423; MGI: 1101357; HomoloGene: 1068; GeneCards: ECE1; OMA:ECE1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.12 Start 21,217,247 bp[1] End 21,345,572 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D3 Start 137,589,548 bp[2] End 137,692,540 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium left adrenal cortex right adrenal gland popliteal artery tibial arteries right adrenal cortex right lung right coronary artery gastric mucosa canal of the cervix Top expressed in aortic valve right lung lobe endothelial cell of lymphatic vessel ascending aorta islet of Langerhans gastrula lip pituitary gland internal carotid artery external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function endopeptidase activity metal ion binding peptide hormone binding peptidase activity protein binding hydrolase activity metallopeptidase activity protein homodimerization activity metalloendopeptidase activity zinc ion binding Cellular component Weibel-Palade body integral component of membrane vesicle endosome membrane lysosomal membrane intrinsic component of endosome membrane perinuclear region of cytoplasm extracellular exosome external side of plasma membrane early endosome plasma membrane Biological process endothelin maturation bradykinin catabolic process regulation of systemic arterial blood pressure by endothelin embryonic digit morphogenesis ear development hormone catabolic process proteolysis development of the heart calcitonin catabolic process regulation of vasoconstriction substance P catabolic process pharyngeal system development positive regulation of receptor recycling protein processing peptide hormone processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1889 230857 Ensembl ENSG00000117298 ENSMUSG00000057530 UniProt P42892 Q4PZA2 RefSeq (mRNA) NM_001113347 NM_001113348 NM_001113349 NM_001397 NM_199307 NM_001369177 NM_001369178 NM_001369179 RefSeq (protein) NP_001106818 NP_001106819 NP_001106820 NP_001388 NP_001106820.1 NP_955011 NP_001356106 NP_001356107 NP_001356108 Location (UCSC) Chr 1: 21.22 – 21.35 Mb Chr 4: 137.59 – 137.69 Mb PubMed search [3] [4]
Wikidata
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Function

Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 (EDN1), -2 (EDN2), and -3 (EDN3) to biologically active peptides.^[5]