EIDD-1723

EIDD-1723, also known as EPRX-01723 or as progesterone 20E-[O-[(phosphonooxy)methyl]oxime] sodium salt, is a synthetic, water-soluble analogue of progesterone and a neurosteroid which was developed for the potential treatment of traumatic brain injury.^[1][2] It is a rapidly converted prodrug of EIDD-036 (EPRX-036; progesterone 20-oxime), which is considered to be the active form of the agent.^[1] Previous C3 and C20 oxime derivatives of progesterone, such as P1-185 (progesterone 3-O-(L-valine)-E-oxime), were also developed and studied prior to EIDD-1723.^[3][4]

EIDD-1723

Clinical data
Other names	Progesterone 20E-[O-[(phosphonooxy)methyl]oxime] sodium salt; Pregn-4-ene-3,20-dione 20E-[O-[(phosphonooxy)methyl]oxime] sodium salt
Drug class	Neurosteroid
Identifiers
IUPAC name Pregn-4-ene-3,20-dione 20E-[O-[(phosphonooxy)methyl]oxime] sodium salt
CAS Number	1659302-89-2 Y
UNII	CYX279XF56
Chemical and physical data
Formula	C22H32NNa2O6P
Molar mass	483.452 g·mol−1
3D model (JSmol)	Interactive image
SMILES C/C([C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O)=N\OCOP([O-])([O-])=O.[Na+].[Na+]
InChI InChI=1S/C22H34NO6P.2Na/c1-14(23-28-13-29-30(25,26)27)18-6-7-19-17-5-4-15-12-16(24)8-10-21(15,2)20(17)9-11-22(18,19)3;;/h12,17-20H,4-11,13H2,1-3H3,(H2,25,26,27);;/q;2*+1/p-2/b23-14+;;/t17-,18+,19-,20-,21-,22+;;/m0../s1 Key:SXDGHAWSHQZKQM-ZZSMYOISSA-L

See also

• List of neurosteroids § Inhibitory > Synthetic > Pregnanes
• List of progestogen esters § Oximes of progesterone derivatives