HuD (protein)

HuD otherwise known as ELAV-like protein 4 is a protein that in humans is encoded by the ELAVL4 gene.^[5][6]

ELAVL4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FXL, 1G2E
Identifiers
Aliases	ELAVL4, HUD, PNEM, HuD, ELAV like neuron-specific RNA binding protein 4, ELAV like RNA binding protein 4
External IDs	OMIM: 168360; MGI: 107427; HomoloGene: 40729; GeneCards: ELAVL4; OMA:ELAVL4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p33-p32.3 Start 50,024,029 bp[1] End 50,203,772 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 C7|4 51.42 cM Start 110,203,722 bp[2] End 110,351,909 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell ganglionic eminence Brodmann area 23 middle temporal gyrus Pons Brodmann area 46 Parietal Lobe postcentral gyrus superior frontal gyrus sperm Top expressed in habenula ventral tegmental area medial vestibular nucleus superior cervical ganglion trigeminal ganglion ganglionic eminence neural tube pontine nuclei medial ganglionic eminence Rostral migratory stream More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 1996 15572 Ensembl ENSG00000162374 ENSMUSG00000028546 UniProt P26378 Q61701 RefSeq (mRNA) NM_001144774 NM_001144775 NM_001144776 NM_001144777 NM_001294348 NM_021952 NM_001324208 NM_001324209 NM_001324212 NM_001324213 NM_001324214 NM_001324215 NM_001324216 NM_001324217 NM_001038698 NM_001163397 NM_001163399 NM_010488 NM_001347178 NM_001357190 RefSeq (protein) NP_001138246 NP_001138247 NP_001138248 NP_001138249 NP_001281277 NP_001311137 NP_001311138 NP_001311141 NP_001311142 NP_001311143 NP_001311144 NP_001311145 NP_001311146 NP_068771 NP_001033787 NP_001156869 NP_001156871 NP_001334107 NP_034618 NP_001344119 Location (UCSC) Chr 1: 50.02 – 50.2 Mb Chr 4: 110.2 – 110.35 Mb PubMed search [3] [4]
Wikidata
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The HuD/ELAVL4 protein is an RNA-binding protein.^[7] HuD contains three RRM protein domains, enabling RNA binding.^[8]

HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity.^[9][10]

Interactions

HuD (protein) has been shown to interact with NXF1.^[11]