Endo-beta-n-acetylglucosaminidase

Endo-beta-N-acetylglucosaminidase is a protein that in humans is encoded by the ENGASE gene.^[5]

ENGASE
Identifiers
Aliases	ENGASE, endo-beta-N-acetylglucosaminidase
External IDs	OMIM: 611898; MGI: 2443788; HomoloGene: 13666; GeneCards: ENGASE; OMA:ENGASE - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 79,074,824 bp[1] End 79,088,599 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 118,476,829 bp[2] End 118,489,209 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon spleen granulocyte pancreatic ductal cell tendon of biceps brachii sural nerve right lobe of thyroid gland left ovary right ovary body of stomach Top expressed in ankle lip yolk sac neural layer of retina thymus duodenum muscle of thigh Paneth cell stomach bone marrow More reference expression data BioGPS n/a
Gene ontology Molecular function hydrolase activity hydrolase activity, acting on glycosyl bonds mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity Cellular component cytoplasm lysosome cytosol Biological process metabolism protein folding protein deglycosylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64772 217364 Ensembl ENSG00000167280 ENSMUSG00000033857 UniProt Q8NFI3 Q8BX80 RefSeq (mRNA) NM_001042573 NM_022759 NM_001396052 NM_001396053 NM_001396054 NM_001396055 NM_172573 NM_001359368 RefSeq (protein) NP_001036038 NP_766161 NP_001346297 NP_001390767 NP_001390768 NP_001390769 NP_001390770 Location (UCSC) Chr 17: 79.07 – 79.09 Mb Chr 11: 118.48 – 118.49 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a cytosolic enzyme which catalyzes the hydrolysis of peptides and proteins with mannose modifications to produce free oligosaccharides. [provided by RefSeq, Feb 2012].