Ectonucleoside triphosphate diphosphohydrolase 7

Ectonucleoside triphosphate diphosphohydrolase 7 is a protein that in humans is encoded by the ENTPD7 gene.^[5]

ENTPD7
Identifiers
Aliases	ENTPD7, LALP1, ectonucleoside triphosphate diphosphohydrolase 7
External IDs	OMIM: 616753; MGI: 2135885; HomoloGene: 122202; GeneCards: ENTPD7; OMA:ENTPD7 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.2 Start 99,659,509 bp[1] End 99,711,241 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C3 Start 43,678,111 bp[2] End 43,722,136 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa buccal mucosa cell duodenum mucosa of ileum sperm secondary oocyte cartilage tissue stromal cell of endometrium mucosa of sigmoid colon testicle Top expressed in jejunum pyloric antrum duodenum intestinal epithelium cumulus cell gastrula epithelium of small intestine motor neuron intestinal villus seminal vesicula More reference expression data BioGPS n/a
Gene ontology Molecular function hydrolase activity metal ion binding nucleoside-triphosphatase activity Cellular component integral component of membrane cytoplasmic vesicle membrane membrane cytoplasmic vesicle endocytic vesicle membrane Biological process nucleobase-containing small molecule catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57089 93685 Ensembl ENSG00000198018 ENSMUSG00000025192 UniProt Q9NQZ7 Q3TCT4 RefSeq (mRNA) NM_020354 NM_001349962 NM_001349963 NM_053103 RefSeq (protein) NP_065087 NP_001336891 NP_001336892 NP_444333 Location (UCSC) Chr 10: 99.66 – 99.71 Mb Chr 19: 43.68 – 43.72 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a purine-converting ectoenzyme which belongs to the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) family. The encoded protein hydrolyzes extracellular nucleoside triphosphates (UTP, GTP, and CTP) to nucleoside monophosphates as part of a purinergic signaling pathway. It contains two transmembrane domains at the N- and C-termini and a large, hydrophobic catalytic domain located in between. This gene affects oxidative stress as well as DNA damage and is a mediator of senescence. [provided by RefSeq, Mar 2017].