EPH receptor A3

EPH receptor A3 (ephrin type-A receptor 3) is a protein that in humans is encoded by the EPHA3 gene.^[5][6][7]

EPHA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GSF, 2QO7, 2QO9, 2QOB, 2QOC, 2QOD, 2QOF, 2QOI, 2QOK, 2QOL, 2QON, 2QOO, 2QOQ, 3DZQ, 3FXX, 3FY2, 4G2F, 4GK2, 4GK3, 4GK4, 4L0P, 4P4C, 4P5Q, 4P5Z, 4TWN, 4TWO
Identifiers
Aliases	EPHA3, Epha3, AW492086, Cek4, ETK1, End3, Hek, Hek4, Mek4, Tyro4, EK4, ETK, EPH receptor A3, HEK, HEK4, TYRO4
External IDs	OMIM: 179611; MGI: 99612; HomoloGene: 21083; GeneCards: EPHA3; OMA:EPHA3 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p11.1 Start 89,107,621 bp[1] End 89,482,134 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C1.3 Start 63,363,897 bp[2] End 63,684,538 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence buccal mucosa cell urethra gallbladder mucosa of urinary bladder tibia Achilles tendon prostate right coronary artery placenta Top expressed in maxillary part of mouth upper jaw ganglionic eminence tongue calvaria medial ganglionic eminence human fetus left lung lobe efferent ductule abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity GPI-linked ephrin receptor activity kinase activity protein binding transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity ATP binding ephrin receptor activity receptor tyrosine kinase transmembrane signaling receptor activity transmembrane-ephrin receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane extracellular region early endosome cytoplasm neuron projection receptor complex Biological process cellular response to retinoic acid regulation of actin cytoskeleton organization fasciculation of motor neuron axon phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway regulation of GTPase activity regulation of epithelial to mesenchymal transition regulation of microtubule cytoskeleton organization protein phosphorylation cell adhesion positive regulation of neuron projection development regulation of focal adhesion assembly fasciculation of sensory neuron axon cell migration ephrin receptor signaling pathway peptidyl-tyrosine phosphorylation negative regulation of endocytosis positive regulation of protein localization to plasma membrane negative regulation of signal transduction cell differentiation negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2042 13837 Ensembl ENSG00000044524 ENSMUSG00000052504 UniProt P29320 P29319 Q8BRB1 RefSeq (mRNA) NM_005233 NM_182644 NM_010140 NM_001362452 RefSeq (protein) NP_005224 NP_872585 NP_034270 NP_001349381 Location (UCSC) Chr 3: 89.11 – 89.48 Mb Chr 16: 63.36 – 63.68 Mb PubMed search [3] [4]
Wikidata
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Function

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene.^[7]

Interactions

EPH receptor A3 has been shown to interact with EFNB2^[8][9] and EFNA5.^[9][10]