Exosome component 3

Exosome component 3, also known as EXOSC3, is a human gene, which is part of the exosome complex.^[5]

EXOSC3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NN6
Identifiers
Aliases	EXOSC3, PCH1B, RRP40, Rrp40p, bA3J10.7, hRrp-40, p10, CGI-102, Exosome component 3
External IDs	OMIM: 606489; MGI: 1913612; HomoloGene: 6867; GeneCards: EXOSC3; OMA:EXOSC3 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p13.2 Start 37,759,234 bp[1] End 37,832,117 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B1 Start 45,316,613 bp[2] End 45,342,732 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte tendon of biceps brachii Achilles tendon right testis left testis gonad stromal cell of endometrium sperm ganglionic eminence Top expressed in tail of embryo genital tubercle embryo embryo yolk sac epiblast zygote spermatid ventricular zone interventricular septum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function 3'-5'-exoribonuclease activity exoribonuclease activity protein binding RNA binding Cellular component cytosol nuclear exosome (RNase complex) cytoplasmic exosome (RNase complex) nucleus cytoplasm exosome (RNase complex) nucleolus nucleoplasm Biological process nuclear polyadenylation-dependent tRNA catabolic process exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) regulation of mRNA stability polyadenylation-dependent snoRNA 3'-end processing DNA deamination CUT catabolic process nuclear polyadenylation-dependent rRNA catabolic process positive regulation of isotype switching isotype switching nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' U4 snRNA 3'-end processing rRNA processing exonucleolytic catabolism of deadenylated mRNA Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51010 66362 Ensembl ENSG00000107371 ENSMUSG00000028322 UniProt Q9NQT5 Q7TQK4 RefSeq (mRNA) NM_016042 NM_001002269 NM_025513 NM_001362788 RefSeq (protein) NP_001002269 NP_057126 NP_079789 NP_001349717 Location (UCSC) Chr 9: 37.76 – 37.83 Mb Chr 4: 45.32 – 45.34 Mb PubMed search [3] [4]
Wikidata
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Clinical significance

Mutations in EXOSC3 cause pontocerebellar hypoplasia and spinal motor neuron degeneration.^[6]