Exosome component 9

Exosome component 9, also known as EXOSC9, is a human gene, the protein product of which (sometimes called RRP45 or PM/Scl-75) is part of the exosome complex and is an autoantigen is patients with certain auto immune diseases, most notably scleromyositis.^[5]

EXOSC9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NN6
Identifiers
Aliases	EXOSC9, PM/Scl-75, PMSCL1, RRP45, Rrp45p, p5, p6, Exosome component 9, PCH1D
External IDs	OMIM: 606180; MGI: 1355319; HomoloGene: 3693; GeneCards: EXOSC9; OMA:EXOSC9 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q27 Start 121,801,318 bp[1] End 121,817,021 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 B Start 36,606,755 bp[2] End 36,619,876 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Achilles tendon gonad testicle buccal mucosa cell left testis right testis ventricular zone ganglionic eminence lymph node Top expressed in otic vesicle otic placode saccule Paneth cell ventricular zone trigeminal ganglion spermatocyte tail of embryo endothelial cell of lymphatic vessel condyle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function 3'-5'-exoribonuclease activity exoribonuclease activity protein binding RNA binding mRNA 3'-UTR AU-rich region binding Cellular component cytoplasm cytosol exosome (RNase complex) nuclear exosome (RNase complex) nuclear chromosome nucleolus extracellular exosome nucleus nucleoplasm cytoplasmic exosome (RNase complex) Biological process RNA processing regulation of mRNA stability nuclear polyadenylation-dependent rRNA catabolic process nuclear-transcribed mRNA catabolic process positive regulation of cell growth nuclear mRNA surveillance immune response exonucleolytic catabolism of deadenylated mRNA positive regulation of transcription by RNA polymerase II rRNA processing exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' U1 snRNA 3'-end processing U4 snRNA 3'-end processing U5 snRNA 3'-end processing nuclear polyadenylation-dependent tRNA catabolic process nuclear polyadenylation-dependent mRNA catabolic process rRNA catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5393 50911 Ensembl ENSG00000123737 ENSMUSG00000027714 UniProt Q06265 Q9JHI7 RefSeq (mRNA) NM_001034194 NM_005033 NM_019393 RefSeq (protein) NP_001029366 NP_005024 NP_062266 Location (UCSC) Chr 4: 121.8 – 121.82 Mb Chr 3: 36.61 – 36.62 Mb PubMed search [3] [4]
Wikidata
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