Endocannabinoid enhancer

An endocannabinoid enhancer (eCBE) is a type of cannabinoidergic^[1] drug that enhances the activity of the endocannabinoid system by increasing extracellular concentrations of endocannabinoids.^[2][3][4][5] Examples of different types of eCBEs include fatty acid amide hydrolase (FAAH) inhibitors, monoacylglycerol lipase (MAGL) inhibitors, and endocannabinoid transporter (eCBT) inhibitors (or "endocannabinoid reuptake inhibitors" ("eCBRIs")).^[2][3][4][5] An example of an actual eCBE is AM404, the active metabolite of the analgesic paracetamol (acetaminophen; Tylenol) and a dual FAAH inhibitor and eCBRI.^[6][7][8]

See also

• Cannabinoid receptor
• Synthetic cannabinoid
• Cannabinoid receptor antagonist