Endothelin A receptor

Endothelin receptor type A, also known as ET_A, is a human G protein-coupled receptor.^[5]

EDNRA
Identifiers
Aliases	EDNRA, ET-A, ETA, ETA-R, ETAR, ETRA, hET-AR, MFDA, endothelin receptor type A
External IDs	OMIM: 131243; MGI: 105923; HomoloGene: 1478; GeneCards: EDNRA; OMA:EDNRA - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.22-q31.23 Start 147,480,917 bp[1] End 147,544,954 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C1 Start 78,389,660 bp[2] End 78,451,093 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tail of epididymis seminal vesicula visceral pleura urethra endometrium caput epididymis cardiac muscle tissue of right atrium tibia corpus epididymis stromal cell of endometrium Top expressed in genital tubercle Gonadal ridge vas deferens external carotid artery left lung lobe ureter lumbar spinal ganglion atrium dermis internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function endothelin receptor activity G protein-coupled receptor activity signal transducer activity protein binding phosphatidylinositol phospholipase C activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane Biological process smooth muscle contraction response to hypoxia neural crest cell development vasoconstriction head development in utero embryonic development activation of phospholipase C activity respiratory gaseous exchange by respiratory system activation of adenylate cyclase activity regulation of blood pressure endothelin receptor signaling pathway enteric nervous system development heart development artery smooth muscle contraction branching involved in blood vessel morphogenesis cell population proliferation signal transduction positive regulation of cytosolic calcium ion concentration G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway glucose transmembrane transport regulation of glucose transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1909 13617 Ensembl ENSG00000151617 ENSMUSG00000031616 UniProt P25101 Q61614 RefSeq (mRNA) NM_001166055 NM_001256283 NM_001957 NM_001354797 NM_010332 RefSeq (protein) NP_001159527 NP_001948 NP_001341726 NP_034462 Location (UCSC) Chr 4: 147.48 – 147.54 Mb Chr 8: 78.39 – 78.45 Mb PubMed search [3] [4]
Wikidata
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Interactions

Endothelin receptor type A has been shown to interact with HDAC7A^[6] and HTATIP.^[6]

See also

• Endothelin receptor