Enoyl-acyl carrier protein reductase

Enoyl-acyl carrier protein reductase (ENR or FabI) (EC 1.3.1.9), is a key enzyme of the type II fatty acid synthesis (FAS) system.^[1] ENR is an attractive target for narrow-spectrum antibacterial drug discovery because of its essential role in metabolism and its sequence conservation across many bacterial species. In addition, the bacterial ENR sequence and structural organization are distinctly different from those of mammalian fatty acid biosynthesis enzymes.^[2]

Enoyl-acyl carrier protein reductase
Enoyl-[acyl-carrier-protein] reductase [NADH] tetramer, Mycobacterium tuberculosis
Identifiers
EC no.	1.3.1.9
CAS no.	37251-08-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

At lower concentrations, Triclosan and Triclocarban provide a bacteriostatic effect by binding to ENR. Atromentin and leucomelone possess antibacterial activity, inhibiting the enzyme in the bacteria Streptococcus pneumoniae.^[3]

See also

• Enoyl-(acyl-carrier-protein) reductase (NADPH, A-specific)
• Enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific)
• Cis-2-enoyl-CoA reductase (NADPH)