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Estradiol benzoate/estradiol phenylpropionate
Combination drug From Wikipedia, the free encyclopedia
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Estradiol benzoate/estradiol phenylpropionate (EB/EPP), sold under the brand name Dimenformon Prolongatum, is an injectable combination formulation of estradiol benzoate (EB), a shorter-acting estrogen, and estradiol phenylpropionate (EPP), a longer-acting estrogen, which has been used in menopausal hormone therapy for women in Europe but appears to no longer be available.[1][2][3][4] It has also been used to suppress lactation in women and has been used in feminizing hormone therapy for transgender women.[5][6] It has been provided in the form of 1 mL ampoules containing 2.5 mg EB and 10 mg EPP in oil solution and is administered by intramuscular injection at regular intervals.[2]
The pharmacokinetics of this formulation and its constituent components have been studied.[7][8][9][10][11][12]
A combination of 12.5 mg EB and 10 mg EPP (developmental code name Org 369–2) has been studied for use in women as a postcoital contraceptive within 48 hours of unprotected sex.[13][9][14][15][16]
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